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UK-370106

CAT: 0804-HY-107639-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107639-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UK-370106 is a potent and highly selective MMP-3 (IC50 of 23 nM) and MMP-12 (IC50 of 42 nM) inhibitor with >1200-fold higher potency than MMP-1, MMP-2, MMP-9, and MMP-14, and about 100-fold than MMP-13 and MMP-8. UK-370106 potently inhibits cleavage of [3H]-fibronectin by MMP-3 (IC50 of 320 nM) and has little effect on keratinocyte migration in vitro[1][2].
CAS Number
230961-21-4
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/uk-370106.html
Concentration
10mM
Purity
99.0
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
CC1=C(C2=CC=CC=C2)C=CC(CCC[C@H](CC(O)=O)C(N[C@@H](C(C)(C)C)C(N[C@@H](C3=CC=CC=C3)COC)=O)=O)=C1
Molecular Formula
C35H44N2O5
Molecular Weight
572.73
References & Citations
[1]Fray MJ, et al. A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. J Med Chem. 2003 Jul 31;46 (16) :3514-25.|[2]Whitlock GA, et al. A novel series of highly selective inhibitors of MMP-3. Bioorg Med Chem Lett. 2007 Dec 15;17 (24) :6750-3. Epub 2007 Oct 17.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-12; MMP-13; MMP-14; MMP-2; MMP-3; MMP-7; MMP-8; MMP-9

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