UK-101

CAT: 0804-HY-119037-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-119037-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
UK-101 is a potent and selective immunoproteasome β1i (LMP2) inhibitor with an IC50 value of 104 nM, displays 144- and 10-fold selectivity over β1c (IC50=15 μM) and β5 subunit (IC50=1 μM), respectivey[1]. UK-101 induces cell apoptosis and can be used for the study of prostate cancer[2].
CAS Number
[1000313-40-5]
UNSPSC
12352005
Target
Apoptosis; Proteasome
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/uk-101.html
Purity
99.58
Solubility
DMSO : 7.3 mg/mL (ultrasonic; warming)
Smiles
O=C([C@]1(CO1)CO[Si](C)(C)C(C)(C)C)[C@H](CC(C)C)NC([C@H](C)NC(CCCCCC)=O)=O
Molecular Formula
C25H48N2O5Si
Molecular Weight
484.74
References & Citations
[1]de Bruin G, et al. Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes. J Med Chem. 2014 Jul 24;57 (14) :6197-209.|[2]Wehenkel M, et al. A selective inhibitor of the immunoproteasome subunit LMP2 induces apoptosis in PC-3 cells and suppresses tumour growth in nude mice. Br J Cancer. 2012 Jun 26;107 (1) :53-62.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-15475-01UK-5099
HY-19965UK-2A
HY-117181UK-1745
HY-107046-01UK-432097
HY-122052-01UK‑396082
HY-129690UK-356202
HY-107639-01UK-370106
HY-19420UK 357903
HY-123293UK 34787
HY-113964UK-78282

Alternative Products

CatalogName
M10004-01UK-101
MBS3604369-01UK-396082
MBS3604134-01UK-369003
MBS3845241-01UK-240455
M18461-01UK 383367
M21048-01UK 088800
MBS3841010-01UK 370106
GL9453-1mgUK-1
MF-0038539-01Uk-390957
sc-361392AUK 356618

Popular Products