UK-101

• Target:

  Apoptosis|||Proteasome

• Related Pathways:

  Apoptosis|||Proteases/Proteasome|||Ubiquitination

• Purity:

  >99.99%

• Bioactivity:

  UK-101 is a potent and selective inhibitor of the immunoproteasome LMP2, inhibiting ?1i (LMP2), ?1c (LMP2), and ?5 (LMP2), with IC50s of 104 nM, 15 ?M, and 1 ?M, respectively. UK-101 exhibits a 144-fold and 10-fold higher affinity for ?1i than for the distribution of ?1c and ?5 subunits. UK-101 induces apoptosis and can be used to study prostate cancer-related diseases.

• Smiles:

  C([C@@H](NC([C@@H](NC(CCCCCC)=O)C)=O)CC(C)C)(=O)[C@@]1(CO[Si](C(C)(C)C)(C)C)CO1

• Molecular Formula:

  C25H48N2O5Si

• Molecular Weight:

  484.74

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1000313-40-5