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UK-101

CAT: 0931-T13247-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T13247-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1000313-40-5
Target
Apoptosis, Proteasome
Related Pathways
Apoptosis, Proteases/Proteasome, Ubiquitination
Purity
>99.99%
Bioactivity
UK-101 is a potent and selective inhibitor of the immunoproteasome LMP2, inhibiting β1i (LMP2), β1c (LMP2), and β5 (LMP2), with IC50s of 104 nM, 15 μM, and 1 μM, respectively. UK-101 exhibits a 144-fold and 10-fold higher affinity for β1i than for the distribution of β1c and β5 subunits. UK-101 induces apoptosis and can be used to study prostate cancer-related diseases.
Smiles
C([C@@H](NC([C@@H](NC(CCCCCC)=O)C)=O)CC(C)C)(=O)[C@@]1(CO[Si](C(C)(C)C)(C)C)CO1
Molecular Formula
C25H48N2O5Si
Molecular Weight
484.74
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

1000313-40-5

PubChem
cas1000313-40-5
modify2026-05-17
synonyms
UK-1011000313-40-5CHEMBL3319605orb1708295SCHEMBL13523660BDBM50099954AKOS040740487DA-58871TS-07906HY-119037+ 15 more
PubChem LinkClick here

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