CHMFL-KIT-033

• Description:

  CHMFL-KIT-033 is a potent and selective inhibitor of c-KIT T670I mutant for gastrointestinal stromal tumors (GISTs), with an IC50 of 0.045 μM[1].

• UNSPSC:

  12352005

• Target:

  C-Kit

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/chmfl-kit-033.html

• Concentration:

  10mM

• Purity:

  99.74

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(CC(NC1=CC=CC(F)=C1)=O)NC2=CC(NN=C3/C=C/C4=CC=CC=N4)=C3C=C2

• Molecular Formula:

  C23H18FN5O2

• Molecular Weight:

  415.42

• References & Citations:

  [1]Liu X, et al. Discovery of (E) - N1- (3-Fluorophenyl) - N3- (3- (2- (pyridin-2-yl) vinyl) -1 H-indazol-6-yl) malonamide (CHMFL-KIT-033) as a Novel c-KIT T670I Mutant Selective Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs) . J Med Chem. 2019 May 23;62 (10) :5006-5024.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2351801-41-5