CHMFL-BMX-078

• Description:

  CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.

• Product Name Alternative:

  CHMFL-BMX 078

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  BMX Kinase

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/CHMFL-BMX-078.html

• Concentration:

  10mM

• Purity:

  98.0

• Solubility:

  DMSO : ≥ 30 mg/mL

• Smiles:

  O=C(C1=CN=C(NC2=CC=C(C)C(NC(C=C)=O)=C2)N=C1NC)NC3=CC(NC(C4=CC(OC)=C(OC)C(OC)=C4)=O)=CC=C3C

• Molecular Formula:

  C33H35N7O6

• Molecular Weight:

  625.67

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Liang X, et al. Discovery of 2- ((3-Acrylamido-4-methylphenyl) amino) -N- (2-methyl-5- (3,4,5-trimethoxybenzamido) phenyl) -4- (methylamino) pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor. J Med Chem. 2017 Mar 9;60 (5) :1793-1816.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1808288-51-8]