FERb 033

• Description :

  FERb 033 is a selective and potent ERβ agonist (Ki=7.1 nM, EC50=4.8 nM) . FERb 033 shows 62-fold selectivity over ERα[1].

• UNSPSC :

  12352005

• Target :

  Estrogen Receptor/ERR

• Type :

  Reference compound

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/ferb-033.html

• Solubility :

  10 mM in DMSO

• Smiles :

  ClC1=C(C2=CC(F)=C(O)C=C2)C=CC(/C=N/O)=C1O

• Molecular Formula :

  C13H9ClFNO3

• Molecular Weight :

  281.67

• References & Citations :

  [1]Filippo Minutolo, et al. Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta. J Med Chem. 2009 Feb 12;52 (3) :858-67.|[2]Satomi Kohno, et al. Estrogen receptor 1 (ESR1; ERα), not ESR2 (ERβ), modulates estrogen-induced sex reversal in the American alligator, a species with temperature-dependent sex determination. Endocrinology. 2015 May;156 (5) :1887-99.|[3]Sangeeta Bhallamudi, et al. Estrogen receptors differentially regulate intracellular calcium handling in human nonasthmatic and asthmatic airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318 (1) :L112-L124.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ERα; ERβ

• CAS Number :

  [1111084-78-6]