CHMFL-KIT-031

• Description:

  CHMFL-KIT-031 is a highly selective KIT V559D inhibitor, with an IC50 of 28 nM. CHMFL-KIT-031 potently affects KIT V559D mutant’s phosphorylation at Y703/719/823 sites. CHMFL-KIT-031 inhibits the tumor growth in BaF3-TEL-KIT-V559D cell inoculated mouse model[1].

• UNSPSC:

  12352005

• Target:

  C-Kit

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Smiles:

  O=C(NCC(NC1=CC2=C(C=C1)C(/C=C/C3=NC=CC=C3)=NN2)=O)C4=CC(OC)=C(OC)C(OC)=C4

• Molecular Formula:

  C26H25N5O5

• Molecular Weight:

  487.51

• References & Citations:

  [1]Yu K, et al. Discovery of a highly selective KIT kinase primary V559D mutant inhibitor for gastrointestinal stromal tumors (GISTs) . Oncotarget. 2017 Nov 15;8 (67) :111110-111118.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported