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CHMFL-PI3KD-317

CAT: 0804-HY-112608-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112608-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC50, 62.6 nM), PI3Kβ (IC50, 284 nM), PI3Kγ (IC50, 202.7 nM), PIK3C2A (IC50, >10000 nM), PIK3C2B (IC50, 882.3 nM), VPS34 (IC50, 1801.7 nM), PI4KIIIA (IC50, 574.1 nM) and PI4KIIIB (IC50, 300.2 nM) . CHMFL-PI3KD-317 inhibits PI3Kδ-mediated Akt T308 phosphorylation in Raji cells, with an EC50 of 4.3 nM. CHMFL-PI3KD-317 has antiproliferative effects on cancer cells[1].
CAS Number
2244992-76-3
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CHMFL-PI3KD-317.html
Purity
98.04
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
ClC1=C(NS(=O)(C2=CC(C)=CC=C2)=O)C=C(C3=C(C)N=C(NC([C@H](C(C)C)N)=O)S3)C=N1
Molecular Formula
C21H24ClN5O3S2
Molecular Weight
494.03
References & Citations
[1]Liang X, et al. Discovery of (S) -2-amino-N- (5- (6-chloro-5- (3-methylphenylsulfonamido) pyridin-3-yl) -4-methylthiazol-2-yl) -3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor. Eur J Med Chem. 2018 Aug 5;156:831-846.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3KC2β; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ; Vps34

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BA8770-1CHMFL-PI3KD-317
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A19990-25CHMFL-PI3KD-317 25mg
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