MT-4

CAT: 0804-HY-128595-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-128595-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

MT-4 is a derivative of a tissue transglutaminase (TG2) inhibitor. MT-4 targets the complex of TG2 and fibronectin (FN) (TG2/FN) and inhibits the adhesion of tumor cells to the matrix. MT-4 inhibits the adhesion of ovarian cancer (OC) cells to the peritoneum and increases the sensitivity of OC cells to paclitaxel.

CAS Number

2327925-35-7

UNSPSC

12352005

Target

Transglutaminase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mt-4.html

Concentration

10mM

Purity

99.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN(C)C1=NC(NC2=CC=C(NC(CC3=CC=CC=C3)=O)C=C2)=NC(C)=C1

Molecular Formula

C21H23N5O

Molecular Weight

361.44

References & Citations

[1]Sima LE, et al. Small Molecules Target the Interaction between Tissue Transglutaminase and Fibronectin. Mol Cancer Ther. 2019 Jun;18 (6) :1057-1068.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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Alternative Products

Catalog	Name
BUP12705-01	MT-4
A18459-50	MT-4 50mg
MBS5804099	Mt KARI-IN-4
A18459-25	MT-4 25mg
A18459-5	MT-4 5mg
A18459-1	MT-4 1mg
A18459-200	MT-4 200mg
A18459-100	MT-4 100mg
A18459-10	MT-4 10mg
CL-0655	MT-4 Cell Line

MT-4

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