MT-4

• Description:

  MT-4 is a derivative of a tissue transglutaminase (TG2) inhibitor. MT-4 targets the complex of TG2 and fibronectin (FN) (TG2/FN) and inhibits the adhesion of tumor cells to the matrix. MT-4 inhibits the adhesion of ovarian cancer (OC) cells to the peritoneum and increases the sensitivity of OC cells to paclitaxel.

• UNSPSC:

  12352005

• Target:

  Transglutaminase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mt-4.html

• Concentration:

  10mM

• Purity:

  99.84

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CN(C)C1=NC(NC2=CC=C(NC(CC3=CC=CC=C3)=O)C=C2)=NC(C)=C1

• Molecular Formula:

  C21H23N5O

• Molecular Weight:

  361.44

• References & Citations:

  [1]Sima LE, et al. Small Molecules Target the Interaction between Tissue Transglutaminase and Fibronectin. Mol Cancer Ther. 2019 Jun;18 (6) :1057-1068.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2327925-35-7]