MT-44

• Description :

  MT-44 is a highly selective and potent mTOR inhibitor with an IC50 of 49.4 nM. MT-44 can inhibit cancer cells proliferation, migration and invasion. MT-44 can induce cells apoptosis and ROS production and cause G2/M phase arrest. MT-44 can activate the cGAS/STING pathway. MT-44 can be used for the research of cancer, such as triple-negative breast cancer[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; mTOR; Reactive Oxygen Species (ROS) ; STING

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

• Field of Research :

  Cancer

• Smiles :

  COC1=CC=C2OC(C3=CC=C4N=C(OC4=C3)N)=C/C(C2=C1)=N\C5=CC=CC=C5NC(CCN)=O

• Molecular Formula :

  C26H23N5O4

• Molecular Weight :

  469.49

• References & Citations :

  [1]Ji-Quan Zhang, et al. Computation-driven discovery of novel chromone derivatives for the treatment of triple-negative breast cancer via mTOR-targeted inhibition and triggering antitumor immunity, Acta Pharmaceutica Sinica B,2025, ISSN 2211-3835.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2966790-70-3]