Products for Research Use Only
RegisterLogin

PF-3882845

CAT: 0804-HY-12738-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-12738-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for hypertension and nephropathy. PF-3882845 also binds to progesterone receptor (PR) with the binding IC50 of 310 nM[1].
CAS Number
1023650-66-9
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Mineralocorticoid Receptor; Progesterone Receptor
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pf-3882845.html
Purity
99.90
Solubility
DMSO : 10 mg/mL (ultrasonic; warming)
Smiles
N#CC1=CC=C(N2N=C(C(C=CC(C(O)=O)=C3)=C3CC4)[C@H]4[C@@H]2C5CCCC5)C=C1Cl
Molecular Formula
C24H22ClN3O2
Molecular Weight
419.90
Precautions
H315, H319, H335
References & Citations
[1]Meyers MJ, et al. Discovery of (3S,3aR) -2- (3-chloro-4-cyanophenyl) -3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy. J Med Chem. 2010 Aug 26;53 (16) :5979-6002.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-P991635PF-07329640
HY-P990645-01PF-03732010
HY-171821-01PF-08046054
HY-123803PF-06807656
HY-120195PF-04677490
HY-108338PF-05139962
HY-108327PF-05020182
HY-19530-01PF-2771
HY-10721-01PF-AKT400
HY-125415-01PF-4693627

Alternative Products

CatalogName
BUP01825-01PF-3882845
MBS579460PF-03084014 (PF-3084014)
BA5950-5.1PF-06928215
BA7028-5PF-4840154
B5563-10PF 5081090
BA8315-10PF-06747711
C4756-10PF-622
A4689-10PF-06409577
BA1871-5.1PF-4878691
BA7829-5.1PF-06840003

Popular Products