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Nav1.7 blocker 1

CAT: 0804-HY-160663Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-160663Size:1 Each
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Description
Nav1.7 blocker 1 (example 41) is a Na+ channel (Nav) blocker with an IC50 value of 0.037 μM. Nav1.7 blocker 1 can be used for the study of pain, including neuropathic pain, postoperative pain, inflammatory pain, and so on[1].
CAS Number
1426336-36-8
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nav1-7-blocker-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC(C2=CC=C(OC3=CC=C(C=C3)F)C=C2)=NC(N4CCOCC4CO)=C1)N
Molecular Formula
C22H21FN4O4
Molecular Weight
424.42
References & Citations
[1]Chiyou Ni, et al. Pyrimidines as sodium channel blockers. WIPO. Patent. WO2013030665. 2013-03-07
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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150978SLC7A11 (Cystine/Glutamate Transporter, Amino Acid Transport System xc-, Calcium Channel Blocker Resistance Protein CCBR1, Solute Carrier Family 7 Member 11, xCT)
MBS646410-01SLC7A11, ID (Cystine/Glutamate Transporter, Amino Acid Transport System xc-, Calcium Channel Blocker Resistance Protein CCBR1, Solute Carrier Family 7 Member 11, xCT)
148503SLC7A11, Control Peptide (Cystine/Glutamate Transporter, Amino Acid Transport System xc-, Calcium Channel Blocker Resistance Protein CCBR1, Solute Carrier Family 7 Member 11, xCT)
S5329-08LSLC7A11 (Cystine/Glutamate Transporter, Amino Acid Transport System xc-, Calcium Channel Blocker Resistance Protein CCBR1, Solute Carrier Family 7 Member 11, xCT) discontinued, see 150978
S5329-08KSLC7A11, ID (Cystine/Glutamate Transporter, Amino Acid Transport System xc-, Calcium Channel Blocker Resistance Protein CCBR1, Solute Carrier Family 7 Member 11, xCT) discontinued. See 150978

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