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MK-4541

CAT: 0804-HY-125065Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-125065Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MK-4541 is an orally active and selective androgen receptor (AR) modulator. MK-4541 acts as an antagonist to inhibit 5α-reductase. MK-4541 inhibits proliferation and induces apoptosis in AR positive prostate cancer cells. MK-4541 significantly inhibited the growth of R3327-G prostate tumors in xenograft mouse model[1].
CAS Number
796885-38-6
UNSPSC
12352005
Target
5 alpha Reductase; Androgen Receptor
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/mk-4541.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])N(C(C=C2)=O)C)([H])[C@@]4([H])[C@@](C)([C@@H](NC(OCC(F)(F)F)=O)CC4)CC3
Molecular Formula
C22H31F3N2O3
Molecular Weight
428.49
References & Citations
[1]Chisamore MJ, et al. A novel selective androgen receptor modulator (SARM) MK-4541 exerts anti-androgenic activity in the prostate cancer xenograft R-3327G and anabolic activity on skeletal muscle mass & function in castrated mice. J Steroid Biochem Mol Biol. 2016 Oct;163:88-97.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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