MK-4541

• Description :

  MK-4541 is an orally active and selective androgen receptor (AR) modulator. MK-4541 acts as an antagonist to inhibit 5α-reductase. MK-4541 inhibits proliferation and induces apoptosis in AR positive prostate cancer cells. MK-4541 significantly inhibited the growth of R3327-G prostate tumors in xenograft mouse model[1].

• UNSPSC :

  12352005

• Target :

  5 alpha Reductase; Androgen Receptor

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Cancer; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/mk-4541.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])N(C(C=C2)=O)C)([H])[C@@]4([H])[C@@](C)([C@@H](NC(OCC(F)(F)F)=O)CC4)CC3

• Molecular Formula :

  C22H31F3N2O3

• Molecular Weight :

  428.49

• References & Citations :

  [1]Chisamore MJ, et al. A novel selective androgen receptor modulator (SARM) MK-4541 exerts anti-androgenic activity in the prostate cancer xenograft R-3327G and anabolic activity on skeletal muscle mass & function in castrated mice. J Steroid Biochem Mol Biol. 2016 Oct;163:88-97.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [796885-38-6]