DS-6930

CAT: 0804-HY-124581Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-124581Size:1 Each

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Description

DS-6930 is a potent and selective agonist of PPARγ, with an EC50 of 41 nM. DS-6930 could robust reduce plasma glucose (PG), and with fewer PPARγ-related adverse effects than Rosiglitazone. DS-6930 can be used for the research of diabetes[1].

CAS Number

1242328-82-0

UNSPSC

12352005

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ds-6930.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C1=CC=CC(OCC2=NC3=CC=C(OC4=NC=C(C)C=C4C)C=C3N2C)=C1

Molecular Formula

C23H21N3O4

Molecular Weight

403.43

References & Citations

[1]Shinozuka T, et, al. Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization. Bioorg Med Chem. 2018 Oct 1;26 (18) :5099-5117.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

PPARγ

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