UC-857993

• Description:

  UC-857993 is a selective SOS1-Ras inhibitor (Kd=14.7 μM, His6-SOS1cat), suppressing catalytic activity. UC-857993 also inhibits ERK and Ras activation, suppresses the growth of mouse embryonic fibroblasts (MEFs) [1].

• UNSPSC:

  12352005

• Target:

  ERK; Ras; SOS1

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/uc-857993.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC2=C3N(C(C4=CC=CC=C4Cl)C5C2C=CC5)CC(CC=C6)C6C3=C1)O

• Molecular Formula:

  C25H22ClNO2

• Molecular Weight:

  403.90

• References & Citations:

  [1]Evelyn CR, et al. Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. J Biol Chem. 2015 May 15;290 (20) :12879-98.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [487001-04-7]