UC-112

• UNSPSC Description:

  UC-112 is a new and highly effective inhibitor of apoptosis inhibitory protein IAP, with an IC50 value of 0.7-3.4uM in cancer cells.

• Target Antigen:

  Apoptosis; IAP

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/UC-112.html

• Purity:

  98.92

• Solubility:

  DMSO : 33.33 mg/mL (ultrasonic)

• Smiles:

  OC1=C2N=CC=CC2=C(COCC3=CC=CC=C3)C=C1CN4CCCC4

• Molecular Weight:

  348.44

• References & Citations:

  [1]Wang J, et al. Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors. J Pharmacol Exp Ther. 2014 May;349(2):319-29.|[2]Qinghui Wang, et al. Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors. Eur J Med Chem

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  383392-66-3