UC-773587

• Description:

  UC-773587 is a selective SOS1 catalytic activity inhibitor. UC-773587 binds to the catalytic site of Sos1 over HRas and ITSN (a RhoGEF) and inhibits nucleotide exchange with an IC50 value of 4.5 μM. UC-773587 mappes to the Ras switch II interaction region of the Sos1 catalytic site. UC-773587 can be used for the study of prostate cancer[1][2].

• UNSPSC:

  12352005

• Target:

  SOS1

• Related Pathways:

  MAPK/ERK Pathway

• Field of Research:

  Cancer

• Smiles:

  OC(C=CC1=C2O3)=CC1=CC=C2C(C4=CC=CC=C4C([O-])=O)=C5C3=C6C=CC(C=C6C=C5)=O

• Molecular Formula:

  C28H15O5

• Molecular Weight:

  431.42

• References & Citations:

  [1]Evelyn CR, et al. Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. J Biol Chem. 2015 May 15;290 (20) :12879-98. |[2]Gray JL, et al. Targeting the Small GTPase Superfamily through Their Regulatory Proteins. Angew Chem Int Ed Engl. 2020 Apr 16;59 (16) :6342-6366.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [116679-70-0]