Products for Research Use Only
RegisterLogin

HG-6-63-01

CAT: 0931-T200330-01Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T200330-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
2177298-99-4
Target
C-RET
Related Pathways
Tyrosine Kinase/Adaptors, Apoptosis
Bioactivity
HG-6-63-01 serves as a type II RET tyrosine kinase inhibitor (TKI) . It effectively targets and inhibits REarranged during Transfection (RET) kinase, disrupting signaling pathways in human thyroid cancer cell lines possessing oncogenic RET alleles. Moreover, this compound reduces the phosphorylation and signaling of RET oncogenic mutants. HG-6-63-01 further suppresses the proliferation of fibroblasts transformed by RET/C634R and RET/M918T, as well as thyroid cancer cells with RET mutations, showing potential as a therapeutic option for cancers with oncogenic activation of RET.
Smiles
O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(CC)CC2)C3=CC=C(C(C=CC=4C=NC=5NC=CC5C4Cl)=C3)C
Molecular Formula
C31H31ClF3N5O
Molecular Weight
582.06
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T38653-01HG-7-85-01
T7196-01HG-10-102-01
T4599-01HG-9-91-01
T86575-01HG-7-86-01
T18594-01HG-7-85-01-Decyclopropane
T84745-01HG-7-85-01-NH2
T11559-01HG-12-6
T24871-01TFMB- (S) -2-HG
T17065-01TFMB- (R) -2-HG
T84789-01PH-HG-005-5

Alternative Products

CatalogName
GTR19239034-01HG-6-63-01
M20640-01HG-10-102-01
BA8810-10HG-7-86-01
HY-15776-01HG-9-91-01
2604-25HG-10-012-01
BUP21086-01HG-7-85-01
M10475HG-7-27-01

Popular Products