GCS-12–6

• Description :

  GCS-12–6 is a potent Th2-selective NKT cell agonist targeting CD1d protein. GCS-12–6 is promising for research of autoimmune diseases (e.g., inflammatory bowel disease, multiple sclerosis) [1].

• UNSPSC :

  12352211

• Target :

  CD1

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Inflammation/Immunology

• Smiles :

  O[C@@H]([C@H](CO[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)NC(CCCCCCCCCCCNS(=O)(CCCCCC)=O)=O)[C@@H](CCCCCCCCCCCCCC)O

• Molecular Formula :

  C42H84N2O11S

• Molecular Weight :

  825.19

• References & Citations :

  [1]Wen Y, et al. Significantly Boosted Th2-Selective Activity of NKT Cell Agonist Enabled by Sulfonamide Hydrogen-Bond Design. J Med Chem. 2025 Aug 14;68 (15) :15785-15797.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CD1d