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LM-4108

CAT: 0804-HY-123639Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123639Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LM-4108 (N- (2-Phenylethyl) -indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC50 of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively[1].
CAS Number
261766-32-9
Product Name Alternative
N- (2-Phenylethyl) -indomethacin amide
UNSPSC
12352005
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lm-4108.html
Purity
90.0
Solubility
10 mM in DMSO
Smiles
O=C(N1C2=C(C(CC(NCCC3=CC=CC=C3)=O)=C1C)C=C(OC)C=C2)C4=CC=C(C=C4)Cl
Molecular Formula
C27H25ClN2O3
Molecular Weight
460.95
References & Citations
[1]Rory P Remmel, et al. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites. Drug Metab Dispos. 2004 Jan;32 (1) :113-22. |[2]Remmel R P, et al. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites. Drug metabolism and disposition, 2004, 32 (1) : 113-122.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2

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