LM-4108

• Description :

  LM-4108 (N- (2-Phenylethyl) -indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC50 of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively[1].

• Product Name Alternative :

  N- (2-Phenylethyl) -indomethacin amide

• UNSPSC :

  12352005

• Target :

  COX

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/lm-4108.html

• Purity :

  90.0

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N1C2=C(C(CC(NCCC3=CC=CC=C3)=O)=C1C)C=C(OC)C=C2)C4=CC=C(C=C4)Cl

• Molecular Formula :

  C27H25ClN2O3

• Molecular Weight :

  460.95

• References & Citations :

  [1]Rory P Remmel, et al. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites. Drug Metab Dispos. 2004 Jan;32 (1) :113-22. |[2]Remmel R P, et al. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites. Drug metabolism and disposition, 2004, 32 (1) : 113-122.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  COX-1; COX-2

• CAS Number :

  [261766-32-9]