LM-305

• Description:

  LM-305 is an anti-G protein-coupled receptor class 5 member D (GPRC5D) antibody-drug conjugate (ADC) . LM-305 consists of Anti-GPRC5D Antibody (HY-P991197) and VcMMAE (HY-15575) . LM-305 exhibits potent cytotoxicity against multiple myeloma cells (NCI-H929 and MM.1R) with IC50 values ranging from 0.1 to 0.3 nM. LM-305 can be used in the study of GPRC5D-related relapsed and refractory multiple myeloma (RRMM) [1].

• UNSPSC:

  12352211

• Target:

  Antibody-Drug Conjugates (ADCs)

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Field of Research:

  Cancer

• Smiles:

  [LM-305]

• References & Citations:

  [1]Wentao Huang, et al. Abstract 6020: Preclinical activity of LM-305 targeting G-protein-coupled receptor class 5 member D (GPRC5D) antibody drug conjugate for the treatment of multiple myeloma. Volume 82, Issue 12_Supplement, 15 June 2022.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported