LM-189

CAT: 0804-HY-171978Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-171978Size:1 Each
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Description
LM-189, a G protein alpha subunit I (Gαi) -biased agonist, is a Gαi-biased ligand of β2-adrenergic receptor (β2AR) . LM-189 stabilizes a distinct conformation in TM6 and increases the dynamics of ICL2. LM-189 can be used to develop the Gαi-biased β2AR agonists[1].
UNSPSC
12352005
Target
Adrenergic Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cardiovascular Disease
Purity
96.58
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC=C([C@@H](O)CNCCCCCCOCCCCC2=CC=CC=C2)C=C1O.O=C(O)C(F)(F)F
Molecular Formula
C26H36F3NO6
Molecular Weight
515.56
References & Citations
[1] Casiraghi M, et al. Structure and dynamics determine G protein coupling specificity at a class A GPCR. Sci Adv. 2025 Mar 21;11 (12) :eadq3971.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
β adrenergic receptor

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