BPK-29

• Description :

  BPK-29 is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein (such RBM45 and SNW1) interactions by covalently modifying C274. BPK-29 impairs the anchorage-independent growth of KEAP1-mutant cancer cells[1].

• UNSPSC :

  12352005

• Target :

  Keap1-Nrf2

• Type :

  Reference compound

• Related Pathways :

  NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/bpk-29.html

• Purity :

  99.4

• Solubility :

  DMSO : 52 mg/mL (ultrasonic; warming)

• Smiles :

  O=C(N(C1CCN(C(C2=CC=C(N3CCOCC3)C=C2)=O)CCC1)CC4=CC=CC=C4)CCl

• Molecular Formula :

  C26H32ClN3O3

• Molecular Weight :

  470.00

• References & Citations :

  [1]Bar-Peled L, et al. Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer. Cell. 2017 Oct 19;171 (3) :696-709.e23.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2143467-62-1]