ASP7657 (free base)

ASP7657 (free base)

• CAS Number: 1196045-28-9
• UNSPSC Description: ASP7657 free base is an orally active EP4 receptor antagonist, with Kis of 2.21 and 6.02 nM for the human and rat EP4 receptors[1].
• Target Antigen: Prostaglandin Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/asp7657-free-base.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@H]1CC[C@H](CNC(C2=CC(C(F)(F)F)=CC3=C2N(CC4=NC5=CC=CC=C5C=C4)C=C3)=O)CC1)O
• Molecular Weight: 509.52
• References & Citations: [1]Mizukami K, et al. Pharmacological properties of ASP7657, a novel, potent, and selective prostaglandin EP4 receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1319-1326.
• Shipping Conditions: Room temperature
• Clinical Information: Phase 1