Nek2-IN-5

Nek2-IN-5

• CAS Number: 1507367-00-1
• UNSPSC Description: Nek2-IN-5 (compound 6) is a potent and irreversible Nek2 ((Never in mitosis gene a)-related kinase 2) inhibitior[1]. Nek2-IN-5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
• Target Antigen: NEKs
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/nek2-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(CC1=CC=CC(NC2=NC(C#C)=C3N=CNC3=N2)=C1)N
• Molecular Weight: 292.30
• References & Citations: [1]Lebraud H, et al. Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles. Org Biomol Chem. 2014 Jan 7;12(1):141-8.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported