NEK2, Active

CAT: 0026-7719-5Size: 5 µgDry Ice: YesHazardous: No
CAT#:0026-7719-5Size:5 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Nek 2 is closely related in its catalytic domain to the serine/threonine protein kinase NIMA of Aspergillus nidulans that is required for entry into mitosis and may function in parallel to the universal mitotic inducer p34cdc2. Like NIMA, the Nek2 protein is almost undetectable during G1 but accumulated progressively throughout S, reaching maximal levels in late G2 (1). These observations demonstrate that Nek2 resembles Aspergillus NIMA, not only in its catalytic domain, but also in its cell cycle-dependent expression. Recombinant Nek2 is active as a serine/threonine-specific protein kinase and may undergo autophosphorylation. Both human Nek2 and fungal NIMA phosphorylate a similar, albeit not identical, set of proteins and synthetic peptides, and β-casein is a suitable substrate for assaying Nek2 in vitro (2). Nek2 is shown to be expressed most abundantly in the testis of the adult tissues examined (3). Its expression in the testis is restricted to the germ cells, with highest levels detected in spermatocytes at pachytene and diplotene stages. Immunohistochemical analysis revealed that Nek2 localized to nuclei, exhibiting a non-uniform distribution within the nucleus.
Shipping Conditions
dry ice
Storage Conditions
-80°C
Shelf Life
12 months

Related Products

CatalogName
7716-5NEK6, Active
7717-5NEK7, Active
B2924-25Nek2/Hec1 inhibitor
B2924-5Nek2/Hec1 inhibitor
7720-5HCK, Active
7703-5Akt3, Active
7730-5PIM2, Active
7752-5ZAP70, Active
7753-5PKCepsilon, Active
7756-5p38alpha, Active

Alternative Products

CatalogName
MBS517304-01NEK2, Active
B2022263NEK2 Protein, Active
HY-P702739-01NEK2, Human (Active)
GWB-571315NEK2, Active Human Recombinant Protein
3706-KS-010Recombinant Human Active NEK2 CF
MBS635709-01NEK2, active, Recombinant, Human (NIMA-Related Kinase 2, Never in mitosis A)
220090NEK2, Active, Recombinant, Human (NIMA-Related Kinase 2, Never in Mitosis A) discontinued
MBS8562632-01NEK2
486747NEK2 (Serine/Threonine-Protein Kinase Nek2)
MBS8516730-01NEK2 Antibody

Popular Products