PF-06456384

• Description:

  PF-06456384 is a highly potent and selective NaV1.7 inhibitor with an IC50 of 0.01 nM. PF-06456384 has the potential for formalin pain model research[1].

• UNSPSC:

  12352005

• Target:

  Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/pf-06456384.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N#CC1=CC (S (=O) (NC2=NC=NS2) =O) =CC=C1OC3=CC=C (C4=CC (C (F) (F) F) =CC=C4) C=C3C5=CC (CNCCC6CCNCC6) =NC=C5

• Molecular Formula:

  C35H32F3N7O3S2

• Molecular Weight:

  719.80

• References & Citations:

  [1]R Ian Storer, et al. Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes. Bioorg Med Chem Lett. 2017 Nov 1;27 (21) :4805-4811.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Nav1.7

• CAS Number:

  1834610-73-9