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Hsp90-IN-42

CAT: 0804-HY-176279Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176279Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hsp90-IN-42 (Compound 13l) is a potent heat shock protein 90 (Hsp90) inhibitor (IC50=15.65 nM) . Hsp90-IN-42 reduces the stability of the epidermal growth factor receptor (EGFR), suppressing the activation of the EGFR-Akt signaling pathway, inducing G0/G1 phase arrest in colorectal cancer cells (such as HT-29 cells), and slightly triggering apoptosis. Hsp90-IN-42 also inhibits cell proliferation and migration by down-regulating the expression of CDK12, CDK13, and Bcl-2 proteins, and up-regulating the expression of Bax protein. Hsp90-IN-42 is promising for research of colorectal cancer[1].
UNSPSC
12352005
Target
HSP
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(F)C=C1)C2=CC=C(O[C@@H]3CN(CC4=CC=CC=C4)[C@]5([H])CC[C@@]3([H])C5)C=C2
Molecular Formula
C27H27FN2O2
Molecular Weight
430.51
References & Citations
[1]Zhang Y, et al. Novel E-F ring derivatives of aconitine scaffold as potent Hsp90 inhibitors for the treatment of colorectal cancer. Eur J Med Chem. 2025 Oct 15;296:117895.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90

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