BMH-22

CAT: 0804-HY-118723-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-118723-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types[1].
CAS Number
[309726-06-5]
UNSPSC
12352005
Hazard Statement
H314
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bmh-22.html
Purity
98.85
Solubility
DMSO : 4.17 mg/mL (ultrasonic)
Smiles
CC1=C2N=C3N=C(C=C(C3=C(C2=CC(C)=C1)N)C)C
Molecular Formula
C16H17N3
Molecular Weight
251.33
Precautions
H314
References & Citations
[1]RPA194, rRNA synthesis, 45S Rrna, anticancer Karita Peltonen, et al. Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress. Mol Cancer Ther. 2014 Nov;13 (11) :2537-46.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-118912BMH-9
HY-12484-01BMH-21
HY-W459528-0122-Methoxy-22-oxodocosanoic acid
HY-W046348-0122- (tert-Butoxy) -22-oxodocosanoic acid
HY-153950CDK7-IN-22
HY-149031DHODH-IN-22
HY-157384BChE-IN-22
HY-161983Neuraminidase-IN-22
HY-155428ICMT-IN-22
HY-149911GY1-22

Alternative Products

CatalogName
MF-0045650-01BMH-22
5417/10BMH 21
MBS577770BMH-21
MBS5773569BMH-23
BUP17943-01BMH-7
MF-0046672-01BMH-9

Popular Products