BMH-9

• Description :

  BMH-9 (Compound Z54) is a modulator for nuclear receptor subfamily 2, group F, member 6 (NR2F6) (also known as nuclear orphan receptor Ear2) [1]. BMH-9 is an activator for p53 signaling pathway through interaction with DNA. BMH-9 inhibits proliferation of human cancer cells, exhibits antitumor efficacy in NOD-SCID mouse models[1].

• UNSPSC :

  12352005

• Target :

  MDM-2/p53; Orphan Nuclear Receptor; Orphan Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; GPCR/G Protein; Vitamin D Related/Nuclear Receptor

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/bmh-9.html

• Smiles :

  O=C(OCC)C1=C(C2=CC(C)=CC(C)=C2N=C1)NCCCN(C)C

• Molecular Formula :

  C19H27N3O2

• Molecular Weight :

  329.44

• References & Citations :

  [1]Lander HM, et al., Small Molecule Agonists and Antagonists of NR2F6 Activity in Humans. US20180214413.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [457937-39-2]