PF-4479745

• Description:

  PF-4479745 is a potent and selective 5-HT2C receptor agonist (EC50: 10 nM, ki: 15 nM) . PF-4479745 can be used in the research of cardiovascular disease like hypertension[1].

• UNSPSC:

  12352005

• Target:

  5-HT Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/pf-4479745.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CNC1=C2C([C@H](CNCC2)C)=NC(CC3=CC=CC=C3)=N1

• Molecular Formula:

  C17H22N4

• Molecular Weight:

  282.38

• References & Citations:

  [1]R Ian Storer, et al. Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors. J Med Chem. 2014 Jun 26;57 (12) :5258-69.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT2 Receptor; mLAG-3; MUC2; α-1 microglobulin

• CAS Number:

  [1065110-43-1]