PF-4479745

• Description :

  PF-4479745 is a potent and selective 5-HT2C receptor agonist (EC50: 10 nM, ki: 15 nM) . PF-4479745 can be used in the research of cardiovascular disease like hypertension[1].

• CAS Number :

  [1065110-43-1]

• UNSPSC :

  12352005

• Target :

  5-HT Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/pf-4479745.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CNC1=C2C([C@H](CNCC2)C)=NC(CC3=CC=CC=C3)=N1

• Molecular Formula :

  C17H22N4

• Molecular Weight :

  282.38

• References & Citations :

  [1]R Ian Storer, et al. Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors. J Med Chem. 2014 Jun 26;57 (12) :5258-69.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT2 Receptor; mLAG-3; MUC2; α-1 microglobulin