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OPC-14523 (free base)

CAT: 0804-HY-116594Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-116594Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OPC-14523 free base is an orally active sigma and 5-HT1A receptor agonist, with high affinity for sigma receptors (σ1/2 IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM) . OPC-14523 free base shows antidepressant-like activity[1][2].
CAS Number
145969-30-8
UNSPSC
12352005
Target
5-HT Receptor; Sigma Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/opc-14523-free-base.html
Solubility
10 mM in DMSO
Smiles
O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)C4=C(C(OC)=CC=C4)CC1
Molecular Formula
C23H28ClN3O2
Molecular Weight
413.94
References & Citations
[1]Tottori K, et al. Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523. Neuropharmacology. 2001;41 (8) :976-988.|[2]Bermack JE, et al. Effects of the potential antidepressant OPC-14523 [1-[3-[4- (3-chlorophenyl) -1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate] a combined sigma and 5-HT1A ligand: modulation of neuronal activity in the dorsal raphe nucleus. J Pharmacol Exp Ther. 2004;310 (2) :578-583.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-HT1 Receptor; mLAG-3

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