ORM-10921 (free base)

• Description :

  ORM-10921 free base is a selective α-2C adrenergic receptor antagonist with a Ki of 1.4 nM. ORM-10921 free base displays potent antidepressant and antipsychotic-like effects[1].

• UNSPSC :

  12352005

• Target :

  Adrenergic Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/orm-10921-free-base.html

• Purity :

  98.08

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@@]1(CCCN2CCC3=C([C@]12[H])OC4=CC=CC=C43)COC

• Molecular Formula :

  C18H23NO2

• Molecular Weight :

  285.38

• References & Citations :

  [1]Jukka Sallinen, et al. Pharmacological characterisation of a structurally novel α2C-adrenoceptor antagonist ORM-10921 and its effects in neuropsychiatric models. Basic Clin Pharmacol Toxicol. 2013 Oct;113 (4) :239-49.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  α adrenergic receptor

• CAS Number :

  [610782-82-6]