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ORM-10921 (free base)

CAT: 0804-HY-114814-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114814-01Size:1 mg
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Description
ORM-10921 free base is a selective α-2C adrenergic receptor antagonist with a Ki of 1.4 nM. ORM-10921 free base displays potent antidepressant and antipsychotic-like effects[1].
CAS Number
610782-82-6
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/orm-10921-free-base.html
Purity
98.08
Solubility
10 mM in DMSO
Smiles
C[C@@]1(CCCN2CCC3=C([C@]12[H])OC4=CC=CC=C43)COC
Molecular Formula
C18H23NO2
Molecular Weight
285.38
References & Citations
[1]Jukka Sallinen, et al. Pharmacological characterisation of a structurally novel α2C-adrenoceptor antagonist ORM-10921 and its effects in neuropsychiatric models. Basic Clin Pharmacol Toxicol. 2013 Oct;113 (4) :239-49.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
α adrenergic receptor

Chemical Information

Orm-12741

ORM-12741 has been used in trials studying the basic science and treatment of Alzheimer's Disease.

CAS Number610782-82-6
PubChem CID71301276
IUPAC Name(1S,12bS)-1-(methoxymethyl)-1-methyl-2,3,4,6,7,12b-hexahydro-[1]benzofuro[2,3-a]quinolizine
Molecular FormulaC18H23NO2
Molecular Weight285.4
XLogP3.3
Topological Polar Surface Area25.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity387
SMILES
C[C@@]1(CCCN2[C@@H]1C3=C(CC2)C4=CC=CC=C4O3)COC
InChI
InChI=1S/C18H23NO2/c1-18(12-20-2)9-5-10-19-11-8-14-13-6-3-4-7-15(13)21-16(14)17(18)19/h3-4,6-7,17H,5,8-12H2,1-2H3/t17-,18-/m1/s1
InChIKey
OCUKPFWNSAAHRP-QZTJIDSGSA-N
Chemical Structure
2D Structure
2D structure of Orm-12741
CAS: 610782-82-6
CID: 71301276
Formula: C18H23NO2
MW: 285.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight285.4
XLogP33.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass285.172878976
Monoisotopic Mass285.172878976
Topological Polar Surface Area25.6 Ų
Heavy Atom Count21
Formal Charge0
Complexity387
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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