Acetyl coenzyme A (trilithium)

• UNSPSC Description:

  Acetyl-coenzyme A (Acetyl-CoA) trilithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A trilithium regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A trilithium is also a key precursor of lipid synthesis[1][2][3][4].

• Target Antigen:

  Autophagy; Endogenous Metabolite; Oxidative Phosphorylation

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Autophagy;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Metabolic Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/acetyl-coenzyme-a-trilithium.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@H]1[C@@H](O[C@H](COP(OP(OCC(C)([C@H](O)C(NCCC(NCCSC(C)=O)=O)=O)C)(O[Li])=O)(O[Li])=O)[C@H]1OP(O)(O[Li])=O)N2C3=C(C(N)=NC=N3)N=C2

• Molecular Weight:

  827.37

• References & Citations:

  [1]Choudhary C, et al. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol. 2014 Aug;15(8):536-50.|[2]Mariño G, et al. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell. 2014 Mar 6;53(5):710-25.|[3]Zhu H, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007 Jul;117(7):1782-93.|[4]Pietrocola F, et al. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 2015 Jun 2;21(6):805-21.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  75520-41-1