Products for Research Use Only
RegisterLogin

Acetyl coenzyme A (trilithium)

CAT: 0804-HY-114293A-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-114293A-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Acetyl-coenzyme A (Acetyl-CoA) trilithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A trilithium regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A trilithium is also a key precursor of lipid synthesis[1][2][3][4].
CAS Number
75520-41-1
Product Name Alternative
Acetyl-CoA (trilithium)
UNSPSC
12352204
Hazard Statement
H315, H319, H335
Target
Autophagy; Endogenous Metabolite; Oxidative Phosphorylation
Type
Biochemical Assay Reagents
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/acetyl-coenzyme-a-trilithium.html
Purity
97
Solubility
10 mM in DMSO
Smiles
CC(SCCNC(CCNC([C@H](O)C(C)(C)COP(OP(OC[C@H]1O[C@@H](N(C=N2)C3=C2C(N)=NC=N3)[C@H](O)[C@@H]1OP(O)(O[Li])=O)(O[Li])=O)(O[Li])=O)=O)=O)=O
Molecular Formula
C23H35Li3N7O17P3S
Molecular Weight
827.37
Precautions
H315, H319, H335
References & Citations
[1]Choudhary C, et al. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol. 2014 Aug;15 (8) :536-50.|[2]Mariño G, et al. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell. 2014 Mar 6;53 (5) :710-25.|[3]Zhu H, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007 Jul;117 (7) :1782-93.|[4]Pietrocola F, et al. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 2015 Jun 2;21 (6) :805-21.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Enzyme
Clinical Information
No Development Reported

Chemical Information

acetylcoenzyme a, trilithium salt
CAS Number75520-41-1
PubChem CID16218870
IUPAC Nametrilithium;[(2R,3S,4R,5R)-2-[[[[(3R)-4-[[3-(2-acetylsulfanylethylamino)-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutoxy]-oxidophosphoryl]oxy-oxidophosphoryl]oxymethyl]-5-(6-aminopurin-9-yl)-4-hydroxyoxolan-3-yl] hydrogen phosphate
Molecular FormulaC23H35Li3N7O17P3S
Molecular Weight827.5
Topological Polar Surface Area397
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count22
Rotatable Bond Count20
Heavy Atom Count54
Formal Charge0
Complexity1360
SMILES
[Li+].[Li+].[Li+].CC(=O)SCCNC(=O)CCNC(=O)[C@@H](C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)[O-])O
InChI
InChI=1S/C23H38N7O17P3S.3Li/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30;;;/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38);;;/q;3*+1/p-3/t13-,16-,17-,18+,22-;;;/m1.../s1
InChIKey
FTRFBNATWBKIQU-JHJDYNLLSA-K
Chemical Structure
2D Structure
2D structure of acetylcoenzyme a, trilithium salt
CAS: 75520-41-1
CID: 16218870
Formula: C23H35Li3N7O17P3S
MW: 827.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight827.5
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count22
Rotatable Bond Count20
Exact Mass827.1503101
Monoisotopic Mass827.1503101
Topological Polar Surface Area397 Ų
Heavy Atom Count54
Formal Charge0
Complexity1360
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count4
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-128851A-01Coenzyme A (trilithium)
HY-134438Hexanoyl coenzyme A (trilithium)
HY-141479DButyryl-Coenzyme A (trilithium)
HY-134129A-01Benzoyl coenzyme A (trilithium)
HY-114293Acetyl coenzyme A
HY-114293RAcetyl coenzyme A (Standard)
HY-114293S5-01Acetyl coenzyme A-d3
HY-113596-01Acetyl Coenzyme A (trisodium)
HY-113596A-01Acetyl coenzyme A (lithium)
HY-137697BDdCTP (trilithium)

Alternative Products

CatalogName
NA46990-01Acetyl coenzyme A trilithium
BIA1091Acetyl-Coenzyme A Trilithium Salt
sc-214465DAcetyl coenzyme A trilithium salt
GTR19240641-01Acetyl Coenzyme A, Trilithium salt
sc-291794Acetyl Coenzyme A Trilithium Salt Trihydrate
26904-01Acetyl Coenzyme A Trilithium Salt extrapure, 90%
295381-01Acetyl coenzyme A trilithium salt discontinued. See 235102
440837-01Acetyl Coenzyme A Trilithium Salt Trihydrate discontinued. See 235102
A-03-50MGCoenzyme A, Trilithium salt
1094-250mgCoenzyme A trilithium, 250mg

Popular Products