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Acetyl coenzyme A (lithium)

CAT: 0804-HY-113596A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113596A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Acetyl-coenzyme A (Acetyl-CoA) lithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A lithium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A lithium is also a key precursor of lipid synthesis[1][2][3][4].
CAS Number
32140-51-5
Product Name Alternative
Acetyl-CoA (lithium)
UNSPSC
12352204
Hazard Statement
H315, H319, H335
Target
Autophagy; Endogenous Metabolite; Oxidative Phosphorylation
Type
Biochemical Assay Reagents
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/acetyl-coenzyme-a-lithium.html
Purity
97
Solubility
10 mM in DMSO
Smiles
O=P(OCC([C@@H](O)C(NCCC(NCCSC(C)=O)=O)=O)(C)C)(O)OP(OC[C@@H]1[C@@H](OP(O)(O)=O)[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1)(O)=O.[xLi]
Molecular Formula
C23H38N7O17P3S
Molecular Weight
809.57
Precautions
H315, H319, H335
References & Citations
[1]Choudhary C, et al. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol. 2014 Aug;15 (8) :536-50.|[2]Mariño G, et al. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell. 2014 Mar 6;53 (5) :710-25. |[3]Zhu H, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007 Jul;117 (7) :1782-93.|[4]Pietrocola F, et al. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 2015 Jun 2;21 (6) :805-21.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Enzyme
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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