Acetyl coenzyme A (Standard)

• UNSPSC Description:

  Acetyl coenzyme A (Standard) is the analytical standard of Acetyl coenzyme A. This product is intended for research and analytical applications. Acetyl-coenzyme A (Acetyl-CoA) is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A is also a key precursor of lipid synthesis[1][2][3][4].

• Target Antigen:

  Autophagy; Endogenous Metabolite; Oxidative Phosphorylation

• Type:

  Reference Standards

• Related Pathways:

  Autophagy;Metabolic Enzyme/Protease

• Field of Research:

  Metabolic Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/acetyl-coenzyme-a-standard.html

• Smiles:

  O[C@H]1[C@@H](O[C@H](COP(OP(OCC(C)([C@@H](O)C(NCCC(NCCSC(C)=O)=O)=O)C)(O)=O)(O)=O)[C@H]1OP(O)(O)=O)N2C3=C(C(N)=NC=N3)N=C2

• Molecular Weight:

  809.57

• References & Citations:

  [1]Choudhary C, et al. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol. 2014 Aug;15(8):536-50. |[2]Mariño G, et al. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell. 2014 Mar 6;53(5):710-25. |[3]Zhu H, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007 Jul;117(7):1782-93. |[4]Pietrocola F, et al. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 2015 Jun 2;21(6):805-21.

• Shipping Conditions:

  Room temperature

• CAS Number:

  72-89-9