Acetyl coenzyme A

• Description:

  Acetyl-coenzyme A (Acetyl-CoA) is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A is also a key precursor of lipid synthesis[1][2][3][4].

• Product Name Alternative:

  Acetyl-CoA

• UNSPSC:

  12352005

• Target:

  Autophagy; Endogenous Metabolite; Oxidative Phosphorylation

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Metabolic Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/acetyl-coenzyme-a.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(SCCNC(CCNC([C@H](O)C(C)(C)COP(OP(O)(OC[C@H]1O[C@@H](N(C=N2)C3=C2C(N)=NC=N3)[C@H](O)[C@@H]1OP(O)(O)=O)=O)(O)=O)=O)=O)=O

• Molecular Formula:

  C23H38N7O17P3S

• Molecular Weight:

  809.57

• References & Citations:

  [1]Choudhary C, et al. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol. 2014 Aug;15 (8) :536-50. |[2]Mariño G, et al. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell. 2014 Mar 6;53 (5) :710-25. |[3]Zhu H, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007 Jul;117 (7) :1782-93. |[4]Pietrocola F, et al. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 2015 Jun 2;21 (6) :805-21.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  72-89-9