AT-121

• Description :

  AT-121 is a bifunctional nociception and mu opioid receptor agonist, with Kis of 3.67 and 16.49 nM, respectively. AT-121 is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H310-H315-H319-H331-H351-H361-H372

• Target :

  Opioid Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/at-121.html

• Concentration :

  2.16 mM * 100 μL in Chloroform

• Purity :

  99.73

• Solubility :

  10 mM in DMSO

• Smiles :

  O=S(N)(NCCN1CC2=C(C=CC=C2)C3(CCN([C@H]4CC[C@@H](C(C)C)CC4)CC3)C1=O)=O

• Molecular Formula :

  C24H38N4O3S

• Molecular Weight :

  462.65

• Precautions :

  P260-P261-P262-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P361+P364-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Ding H, Kiguchi N, Yasuda D, et al. A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates. Sci Transl Med. 2018;10 (456) :eaar3483. doi:10.1126/scitranslmed.aar3483

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Solution, -20°C, 2 years

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  μ Opioid Receptor/MOR

• CAS Number :

  [2099681-31-7]