AT-121

• Description:

  AT-121 is a bifunctional nociception and mu opioid receptor agonist, with Kis of 3.67 and 16.49 nM, respectively. AT-121 is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H310-H315-H319-H331-H351-H361-H372

• Target:

  Opioid Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/at-121.html

• Concentration:

  2.16 mM * 100 μL in Chloroform

• Purity:

  99.73

• Solubility:

  10 mM in DMSO

• Smiles:

  O=S(N)(NCCN1CC2=C(C=CC=C2)C3(CCN([C@H]4CC[C@@H](C(C)C)CC4)CC3)C1=O)=O

• Molecular Formula:

  C24H38N4O3S

• Molecular Weight:

  462.65

• Precautions:

  P260-P261-P262-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P361+P364-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Ding H, Kiguchi N, Yasuda D, et al. A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates. Sci Transl Med. 2018;10 (456) :eaar3483. doi:10.1126/scitranslmed.aar3483

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Solution, -20°C, 2 years

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  μ Opioid Receptor/MOR

• CAS Number:

  2099681-31-7