AT-121

• Target:

  Opioid Receptor

• Related Pathways:

  GPCR/G Protein|||Endocrinology/Hormones|||Neuroscience

• Purity:

  0.9997

• Bioactivity:

  AT-121 is a dual ?-opioid and neuropeptide receptor partial agonist (Kis 16.49 and 3.67 nM, respectively) . It stimulates [35S]GTP?S binding to cell membranes expressing either ?-opioid receptors or neuropeptide receptors (EC50s of 19.6 and 34.7 nM, respectively.) AT-121 (0.003-0.03 mg/kg) reduced capsaicin-induced thermal anisocoria in a dose-dependent manner, but did not increase scratching activity in rhesus monkeys. In rhesus monkey drug self-administration tests, AT-121 at doses of 0.3 to 10 ?g/kg per injection lacked reinforcing effects (a potential marker of abuse) and did not reduce the reinforcing effects of food pellets.AT-121 (0.01 or 0.03 mg/kg) did not induce hyperalgesia, a marker of tolerance, in rhesus monkeys.AT-121 is a safe non-addictive pain reliever with anti-injury and analgesic effects.

• Smiles:

  O=C1C2(C=3C(CN1CCNS(N)(=O)=O)=CC=CC3)CCN(CC2)[C@@H]4CC[C@H]([C@H](C)C)CC4

• Molecular Formula:

  C24H38N4O3S

• Molecular Weight:

  462.65

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2099681-31-7