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AT-121

CAT: 0931-T37610-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T37610-01Size:1 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2099681-31-7
Target
Opioid Receptor
Related Pathways
GPCR/G Protein|||Endocrinology/Hormones|||Neuroscience
Purity
0.9997
Bioactivity
AT-121 is a dual ?-opioid and neuropeptide receptor partial agonist (Kis 16.49 and 3.67 nM, respectively) . It stimulates [35S]GTP?S binding to cell membranes expressing either ?-opioid receptors or neuropeptide receptors (EC50s of 19.6 and 34.7 nM, respectively.) AT-121 (0.003-0.03 mg/kg) reduced capsaicin-induced thermal anisocoria in a dose-dependent manner, but did not increase scratching activity in rhesus monkeys. In rhesus monkey drug self-administration tests, AT-121 at doses of 0.3 to 10 ?g/kg per injection lacked reinforcing effects (a potential marker of abuse) and did not reduce the reinforcing effects of food pellets.AT-121 (0.01 or 0.03 mg/kg) did not induce hyperalgesia, a marker of tolerance, in rhesus monkeys.AT-121 is a safe non-addictive pain reliever with anti-injury and analgesic effects.
Smiles
O=C1C2(C=3C(CN1CCNS(N)(=O)=O)=CC=CC3)CCN(CC2)[C@@H]4CC[C@H]([C@H](C)C)CC4
Molecular Formula
C24H38N4O3S
Molecular Weight
462.65
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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