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BC-1215

CAT: 0804-HY-117937-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117937-01Size:5 mg
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Description
BC-1215 is a F-box protein 3 (Fbxo3) inhibitor. BC-1215 works by antagonizing of Fbxo3 on TRAF cytokine signaling and exhibits a low IC50 in vitro. BC-1215 can be used for the research of inflammation[1].
CAS Number
1507370-20-8
Product Name Alternative
TPEDA
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bc-1215.html
Purity
99.94
Solubility
DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C1(CNCCNCC2=CC=C(C3=NC=CC=C3)C=C2)=CC=C(C4=NC=CC=C4)C=C1
Molecular Formula
C26H26N4
Molecular Weight
394.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Chen BB, et al. A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulateinflammation. Nat Immunol. 2013 May;14 (5) :470-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Fbxo3

Chemical Information

BC-1215

an Fbxo3 inhibitor; structure in first source

CAS Number1507370-20-8
PubChem CID72201045
IUPAC NameN,N'-bis[(4-pyridin-2-ylphenyl)methyl]ethane-1,2-diamine
Molecular FormulaC26H26N4
Molecular Weight394.5
XLogP3.5
Topological Polar Surface Area49.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count9
Heavy Atom Count30
Formal Charge0
Complexity412
SMILES
C1=CC=NC(=C1)C2=CC=C(C=C2)CNCCNCC3=CC=C(C=C3)C4=CC=CC=N4
InChI
InChI=1S/C26H26N4/c1-3-15-29-25(5-1)23-11-7-21(8-12-23)19-27-17-18-28-20-22-9-13-24(14-10-22)26-6-2-4-16-30-26/h1-16,27-28H,17-20H2
InChIKey
IXEPQJQQSLMESJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of BC-1215
CAS: 1507370-20-8
CID: 72201045
Formula: C26H26N4
MW: 394.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight394.5
XLogP33.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count9
Exact Mass394.21574685
Monoisotopic Mass394.21574685
Topological Polar Surface Area49.8 Ų
Heavy Atom Count30
Formal Charge0
Complexity412
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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