MK-8318

• Description :

  MK-8318 is a potent and selective CRTh2 receptor antagonist with a Ki of 5.0 nM.

• UNSPSC :

  12352005

• Target :

  Prostaglandin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Inflammation/Immunology; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/MK-8318.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC1=CC=C(N(C(C2=CC=C(OC(F)(F)F)C=C2)=O)[C@@H](CCC3)[C@@H]3[C@H]4N(C(CCC(O)=O)=O)C5CC5)C4=C1

• Molecular Formula :

  C27H26F4N2O5

• Molecular Weight :

  534.50

• References & Citations :

  [1]Huang X, et al. Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma. ACS Med Chem Lett. 2018 Jun 23;9 (7) :679-684.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  DP

• CAS Number :

  [1416581-40-2]