MK-8318

• Description:

  MK-8318 is a potent and selective CRTh2 receptor antagonist with a Ki of 5.0 nM.

• UNSPSC:

  12352005

• Target:

  Prostaglandin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Inflammation/Immunology; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/MK-8318.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=CC=C (N (C (C2=CC=C (OC (F) (F) F) C=C2) =O) [C@@H] (CCC3) [C@@H]3[C@H]4N (C (CCC (O) =O) =O) C5CC5) C4=C1

• Molecular Formula:

  C27H26F4N2O5

• Molecular Weight:

  534.50

• References & Citations:

  [1]Huang X, et al. Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma. ACS Med Chem Lett. 2018 Jun 23;9 (7) :679-684.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  DP

• CAS Number:

  1416581-40-2