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AZ-3

CAT: 0804-HY-112442Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-112442Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ-3 is a potent and selective JAK1 inhibitor with an IC50 of 34 nM.
CAS Number
2228908-91-4
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZ-3.html
Solubility
10 mM in DMSO
Smiles
FC1=NC=C(N2C[C@H]3N(C)C[C@@H]2C3)C=C1NC4=NC(N[C@@H](CC)C)=C(C)C=N4
Molecular Formula
C20H28FN7
Molecular Weight
385.48
References & Citations
[1]Grimster NP, et al. Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors. J Med Chem. 2018 Jun 28;61 (12) :5235-5244.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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