AZ-3

• Description:

  AZ-3 is a potent and selective JAK1 inhibitor with an IC50 of 34 nM.

• UNSPSC:

  12352005

• Target:

  JAK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/AZ-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=NC=C(N2C[C@H]3N(C)C[C@@H]2C3)C=C1NC4=NC(N[C@@H](CC)C)=C(C)C=N4

• Molecular Formula:

  C20H28FN7

• Molecular Weight:

  385.48

• References & Citations:

  [1]Grimster NP, et al. Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors. J Med Chem. 2018 Jun 28;61 (12) :5235-5244.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2228908-91-4]