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Afabicin (disodium)

CAT: 0804-HY-109000ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-109000ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Afabicin (Debio 1450) is the proagent of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci[1].
CAS Number
1518800-29-7
Product Name Alternative
Debio 1450 (disodium) ; AFN-1720 (disodium)
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/afabicin-disodium.html
Solubility
10 mM in DMSO
Smiles
O=P(O[Na])(O[Na])OCN1C2=NC=C(/C=C/C(N(C)CC(OC3=CC=CC=C43)=C4C)=O)C=C2CCC1=O
Molecular Formula
C23H22N3Na2O7P
Molecular Weight
529.39
References & Citations
[1]Flamm RK, et al. Activity of Debio1452, a FabI inhibitor with potent activity against Staphylococcus aureus and coagulase-negative Staphylococcus spp., including multidrug-resistant strains. Antimicrob Agents Chemother. 2015;59 (5) :2583-2587.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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