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Afabicin

CAT: 0804-HY-109000-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109000-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Afabicin (Debio 1450) is the proagent of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.
CAS Number
1518800-35-5
Product Name Alternative
Debio 1450; AFN-1720
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Afabicin.html
Purity
96.28
Solubility
H2O : 3.85 mg/mL (ultrasonic; warming; adjust pH to 10 with NaOH; heat to 60°C)
Smiles
O=P(O)(O)OCN1C2=NC=C(/C=C/C(N(C)CC(OC3=CC=CC=C43)=C4C)=O)C=C2CCC1=O
Molecular Formula
C23H24N3O7P
Molecular Weight
485.43
References & Citations
[1]Flamm RK, et al. Activity of Debio1452, a FabI inhibitor with potent activity against Staphylococcus aureus and coagulase-negative Staphylococcus spp., including multidrug-resistant strains. Antimicrob Agents Chemother. 2015 May;59 (5) :2583-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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