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Aurothiomalate (disodium)

CAT: 0804-HY-W010270ASize: 1 EachDry Ice: NoHazardous: No
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Description
Aurothiomalate (disodium) is a TRPA1 inhibitor. Aurothiomalate (disodium) inhibits NF-κB activation and iNOS expression. Aurothiomalate (disodium) promotes M2 transformation of macrophages and increases the expression of TREM-2 and arginase-1. Aurothiomalate (disodium) can be used in the study of liver fibrosis/cirrhosis and arthritis[1][2].
CAS Number
74916-57-7
UNSPSC
12352211
Target
Arginase; NF-κB; NO Synthase; TREM receptor; TRP Channel
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
O=C(CC(C([O-])=O)[S-])[O-].[Na+].[Au+].[Na+]
Molecular Formula
C4H3AuNa2O4S
Molecular Weight
390.08
References & Citations
[1]Nummenmaa E, et al. TRPA1 expression is downregulated by dexamethasone and aurothiomalate in human chondrocytes: TRPA1 as a novel factor and drug target in arthritis. RMD Open. 2017 Sep 4;3 (2) :e000556.|[2]강건욱, et al. Pharmaceutical composition, comprising gold compound, for preventing or treating liver fibrosis or liver cirrhosis. WO2016028092A2. 서울대학교 산학협력단. 2015-08-19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
INOS; NF-κB; TREM-2

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