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CPT2

CAT: 0804-HY-108433Size: 50 µgDry Ice: NoHazardous: No
CAT#:0804-HY-108433Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CPT2 (Carnitine palmitoyltransferase 2), an enzyme that participates in fatty acid oxidation, also is a colorectal cancer (CRC) prognostic biomarker. CPT2 overexpression can activate p-p53 to increase p53 expression, thereby inhibiting tumor proliferation and promoting apoptosis. CPT2 deficiency results in the most common inherited disorder of long-chain fatty acid oxidation affecting skeletal muscle. Downregulation of CPT2 is also highly correlated with the progression of various cancers and has potential for cancer research[1][2].
CAS Number
[1670277-66-3]
Product Name Alternative
Carnitine palmitoyltransferase 2
UNSPSC
12352204
Target
Apoptosis; MDM-2/p53
Type
Enzyme
Related Pathways
Apoptosis
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/cpt2.html
Solubility
10 mM in DMSO
Smiles
[CPT2]
References & Citations
[1]Liu F, et al. Downregulation of CPT2 promotes proliferation and inhibits apoptosis through p53 pathway in colorectal cancer. Cell Signal. 2022 Apr;92:110267. |[2]Joshi PR, et al. Muscle Carnitine Palmitoyltransferase II (CPT II) Deficiency: A Conceptual Approach. Molecules. 2020 Apr 13;25 (8) :1784.
Shipping Conditions
Room temperature
Scientific Category
Enzyme
Clinical Information
No Development Reported

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