CPT2

• Description :

  CPT2 (Carnitine palmitoyltransferase 2), an enzyme that participates in fatty acid oxidation, also is a colorectal cancer (CRC) prognostic biomarker. CPT2 overexpression can activate p-p53 to increase p53 expression, thereby inhibiting tumor proliferation and promoting apoptosis. CPT2 deficiency results in the most common inherited disorder of long-chain fatty acid oxidation affecting skeletal muscle. Downregulation of CPT2 is also highly correlated with the progression of various cancers and has potential for cancer research[1][2].

• Product Name Alternative :

  Carnitine palmitoyltransferase 2

• UNSPSC :

  12352204

• Target :

  Apoptosis; MDM-2/p53

• Type :

  Enzyme

• Related Pathways :

  Apoptosis

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Cancer; Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/cpt2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  [CPT2]

• References & Citations :

  [1]Liu F, et al. Downregulation of CPT2 promotes proliferation and inhibits apoptosis through p53 pathway in colorectal cancer. Cell Signal. 2022 Apr;92:110267. |[2]Joshi PR, et al. Muscle Carnitine Palmitoyltransferase II (CPT II) Deficiency: A Conceptual Approach. Molecules. 2020 Apr 13;25 (8) :1784.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Enzyme

• Clinical Information :

  No Development Reported

• CAS Number :

  [1670277-66-3]