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CPTH2 (hydrochloride)

CAT: 0804-HY-W013274ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W013274ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CPTH2 hydrochloride is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 hydrochloride selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 hydrochloride induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B) [1][2].
CAS Number
2108899-91-6
UNSPSC
12352005
Target
Apoptosis; Histone Acetyltransferase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cpth2-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1.[H]Cl
Molecular Formula
C14H15Cl2N3S
Molecular Weight
328.26
References & Citations
[1]Cocco E, et al. KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumoraggressiveness and target of KAT inhibitor CPTH2. Clin Epigenetics. 2018 Apr 4;10:44.|[2]Chimenti F, et al. A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4- (4'-chlorophenyl) thiazol-2-yl) hydrazone. J Med Chem. 2009 Jan 22;52 (2) :530-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GCN5/PCAF

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