CPTH2 (hydrochloride)

CPTH2 (hydrochloride)

• CAS Number: 2108899-91-6
• UNSPSC Description: CPTH2 hydrochloride is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 hydrochloride selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 hydrochloride induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B)[1][2].
• Target Antigen: Apoptosis; Histone Acetyltransferase
• Type: Reference compound
• Related Pathways: Apoptosis;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cpth2-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: ClC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1.[H]Cl
• Molecular Weight: 328.26
• References & Citations: [1]Cocco E, et al. KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumoraggressiveness and target of KAT inhibitor CPTH2. Clin Epigenetics. 2018 Apr 4;10:44.|[2]Chimenti F, et al. A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. J Med Chem. 2009 Jan 22;52(2):530-6.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported