CPT-Se4

• Description :

  CPT-Se4, a selenoproagent of Camptothecin (CPT), shows improved potency in killing cancer cells and inhibiting tumor growth. CPT-Se4 decreases the GSH/GSSG ratio and total thiols, elevates the ROS level in Hep G2 cells, and eventually induces apoptosis of cancer cells. CPT-Se4 shows cytotoxicity against HeLa, Hep G2, A549, and SMMC-7721 cells (IC50= 2.54-6.4 μM) [1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Topoisomerase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cpt-se4.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O[C@]1(C2=C(COC1=O)C(N(C3=C2)CC4=C3N=C5C(C=CC=C5)=C4)=O)CC)OCC[Se][Se]CCO

• Molecular Formula :

  C25H24N2O7Se2

• Molecular Weight :

  622.39

• References & Citations :

  [1]Zhao J, et al. Integration of a Diselenide Unit Generates Fluorogenic Camptothecin Prodrugs with Improved Cytotoxicity to Cancer Cells. J Med Chem. 2021;64 (24) :17979-17991.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2968315-03-7]