CPT-Se4

CAT: 0804-HY-145291Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-145291Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
CPT-Se4, a selenoproagent of Camptothecin (CPT), shows improved potency in killing cancer cells and inhibiting tumor growth. CPT-Se4 decreases the GSH/GSSG ratio and total thiols, elevates the ROS level in Hep G2 cells, and eventually induces apoptosis of cancer cells. CPT-Se4 shows cytotoxicity against HeLa, Hep G2, A549, and SMMC-7721 cells (IC50= 2.54-6.4 μM) [1].
CAS Number
[2968315-03-7]
UNSPSC
12352005
Target
Apoptosis; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cpt-se4.html
Solubility
10 mM in DMSO
Smiles
O=C(O[C@]1(C2=C(COC1=O)C(N(C3=C2)CC4=C3N=C5C(C=CC=C5)=C4)=O)CC)OCC[Se][Se]CCO
Molecular Formula
C25H24N2O7Se2
Molecular Weight
622.39
References & Citations
[1]Zhao J, et al. Integration of a Diselenide Unit Generates Fluorogenic Camptothecin Prodrugs with Improved Cytotoxicity to Cancer Cells. J Med Chem. 2021;64 (24) :17979-17991.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-161095IRGD-CPT
HY-145290CPT-Se3
HY-111469-01CPT-157633
HY-175472(GalNAc) 3-CPT
HY-112667-01CU-CPT-9a
HY-108473-01CU-CPT 4a
HY-112050-01CU-CPT-8m
HY-120994BSp-8-CPT-cAMPS
HY-120994ARp-8-CPT-cAMPS
HY-1342998-CPT-cAMP-AM

Alternative Products

CatalogName
MBS5815562CPT-Se4
525922CPT
YP-W60484-01Chicken CPT (CPT) ELISA Kit
C16232Camptothecin (CPT)
MBS5815561CPT-Se3
BA8101-1CPT-157633
2688/50CPT 11
MF-0116339-01IRGD-CPT
YP-W79171-01Sheep CPT-11 (CPT-11) ELISA Kit
YP-W79170-01Sheep CPT-1 (CPT-1) ELISA Kit

Popular Products