IRGD-CPT

CAT: 0804-HY-161095Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-161095Size:1 Each
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Description
IRGD-CPT is a conjugate of iRGD and camptothecin that is covalently coupled through a heterobifunctional linker. iRGD-CPT has anticancer activity in vitroandin vivo. iRGD-CPT can be used for the study of colon cancer[1].
UNSPSC
12352005
Target
DNA/RNA Synthesis; Integrin; Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/irgd-cpt.html
Solubility
10 mM in DMSO
Smiles
O=C(CC1SC[C@H](NC(C)=O)C(N[C@@H]2C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(NCC(N3CCC[C@H]3C(N[C@H](C(N[C@@H](CSSC2)C(O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)N(CCC(NOCCOCCOCCCC(O[C@]4(CC)C(OCC5=C4C=C6N(CC7=CC8=CC=CC=C8N=C76)C5=O)=O)=O)=O)C1=O
Molecular Formula
C75H100N18O27S3
Molecular Weight
1781.90
References & Citations
[1]Singh, Tejinder et al. Tumor-homing peptide iRGD-conjugate enhances tumor accumulation of camptothecin for colon cancer therapy. European journal of medicinal chemistry, vol. 265 116050. 16 Dec. 2023
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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