Harmol (hydrochloride)

CAT: 0804-HY-107811ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-107811ASize:1 Each
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Description
Harmol hydrochloride is an orally active β-carboline alkaloid. Harmol hydrochloride is a TFEB activator and monoamine oxidase inhibitor. Harmol hydrochloride can induce cell mitosis, Autophagy and Apoptosis. Harmol hydrochloride promotes the degradation of α-synuclein by regulating the autophagy-lysosomal pathway. Harmol hydrochloride has anti-tumor, anti-depressant and anti-aging activities. Harmol hydrochloride improves motor impairment in a mouse Parkinson's disease model[1][2][3][4].
CAS Number
[40580-83-4]
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Apoptosis; Autophagy; Mitosis; Monoamine Oxidase; α-synuclein
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/harmol-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
OC1=CC2=C(C=C1)C3=C(C(C)=NC=C3)N2.[H]Cl
Molecular Formula
C12H11ClN2O
Molecular Weight
234.68
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Jie Xu, et al. Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson's models via regulating autophagy-lysosome pathway. NPJ Parkinsons Dis. 2022 Aug 6;8 (1) :100.|[2]Akihisa Abe , et al. Harmol induces autophagy and subsequent apoptosis in U251MG human glioma cells through the downregulation of surviving. Oncol Rep. 2013 Apr;29 (4) :1333-42. |[3]Akihisa Abe, et al. Harmol induces apoptosis by caspase-8 activation independently of Fas/Fas ligand interaction in human lung carcinoma H596 cells. Anticancer Drugs. 009 Jun;20 (5) :373-81.|[4]Luis Filipe Costa-Machado, et al. Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models. Nat Commun. 2023 May 15;14 (1) :2779.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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