Harmol (hydrochloride)

• Description:

  Harmol hydrochloride is an orally active β-carboline alkaloid. Harmol hydrochloride is a TFEB activator and monoamine oxidase inhibitor. Harmol hydrochloride can induce cell mitosis, Autophagy and Apoptosis. Harmol hydrochloride promotes the degradation of α-synuclein by regulating the autophagy-lysosomal pathway. Harmol hydrochloride has anti-tumor, anti-depressant and anti-aging activities. Harmol hydrochloride improves motor impairment in a mouse Parkinson's disease model[1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H312-H332

• Target:

  Apoptosis; Autophagy; Mitosis; Monoamine Oxidase; α-synuclein

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Autophagy; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cancer; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/harmol-hydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=CC2=C(C=C1)C3=C(C(C)=NC=C3)N2.[H]Cl

• Molecular Formula:

  C12H11ClN2O

• Molecular Weight:

  234.68

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

• References & Citations:

  [1]Jie Xu, et al. Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson's models via regulating autophagy-lysosome pathway. NPJ Parkinsons Dis. 2022 Aug 6;8 (1) :100.|[2]Akihisa Abe , et al. Harmol induces autophagy and subsequent apoptosis in U251MG human glioma cells through the downregulation of surviving. Oncol Rep. 2013 Apr;29 (4) :1333-42. |[3]Akihisa Abe, et al. Harmol induces apoptosis by caspase-8 activation independently of Fas/Fas ligand interaction in human lung carcinoma H596 cells. Anticancer Drugs. 009 Jun;20 (5) :373-81.|[4]Luis Filipe Costa-Machado, et al. Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models. Nat Commun. 2023 May 15;14 (1) :2779.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [40580-83-4]